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As you head south from downtown, the first significant change begins at about Sixth Avenue South, which is where the campus of the University of Alabama at Birmingham (UAB) begins. UAB has one of the most impressive and famous medical centers in the country and regularly attracts some of the world's most renowned surgeons, educators and researchers (as well as some of the world's most famous patients). Locally, though, the Southside is known as the destination for entertainment, nightlife and fine dining.

At the intersection of 20th Street, 11th Avenue South and Magnolia Avenue is Five Points South, the epicenter of the Southside and home to many of the most exciting nightclubs, finest restaurants and hippest retail boutiques in Birmingham. Restaurants such as Highlands Bar and Grill, Cosmos Pizza and the Original Pancake House are all within walking distance, as are several excellent bars and nightclubs, including The 5 Points Grill. This area is also home to many small locally owned shops and boutiques that cater to a generally young Bohemian clientèle.

Excerpt from BhamWiki